PEPTINEX

COLLAGEN PEPTIDE:

NATURALLY PROMOTING

HEALTH AND WELL BEING

When we are younger, collagen production and degradation in our bodies harmoniously balance each other as the tissues mature, the degradation of collagen supersedes the production. [1].

Collagen peptides have been studied for their potential biological benefits [2].
Several scientific studies have demonstrated bioavailability of collagen peptides after oral administration in animals and humans [1].
Collagen peptides are well absorbed by the body. In vivo studies have shown that when administered orally, collagen peptides are rapidly absorbed and reach the bloodstream through the intestines making it readily available for various metabolic processes [3,4].

[1] Dybka K, Walczak P. Collagen Hydrolysates as a New Diet Supplement. Food Chemistry and Biotechnology 73:1058; 2009.[2] Liu D, Nikoo M, Boran G, Zhou P, Regenstein JM. Collagen and Gelatin. Annu. Rev. Food Sci. Technol. 6; 2015. p. 527–57.[3] Watanabe-kamiyama M, Shimizu M, Kamiyama K, Taguchi Y, Sone H, Morimatsu F, Shirakawa H, Furukawa Y, Komai M. Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats. J. Agric. Food Chem. 58; 2010. p. 835–41.[4] Oesser S, Seifert J, Adam M, Babel W. Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL). The Journal Nutrition 129; 1999. p. 1891–5.

Beauty

Age affects the skin, just like all structures of our body. The ability to naturally replenish collagen in the body is diminished with age. As a consequence, we have a reduction in the density of the collagen and elastin fibers, as well as the loss of hyaluronic acid. Some of the most common effects of aging are wrinkles, sagging skin and fine lines [1].

In addition, the skin is affected by external chemical and physical factors, like solar radiation.  Nutrition is also often mentioned because of its influence on skin conditions [2].

Type I collagen is the most abundant in the skin and, together with elastin, form fibers that guarantee structure, elasticity and firmness [3].

A diet rich in collagen peptides has shown significant

improvement in the appearance of the skin particularly with:

Improvement in skin conditions, contributing to positive effects on appearance, elasticity and hydration [4].

It acts as an anti-aging agent aiding in the reduction of wrinkles and facial expression lines [5].

It stimulates the proliferation of fibroblasts, contributing to the synthesis of new collagen fibers [6].

[1] Sibilla S, Godfrey M, Brewer S, Budh-Raja A, Genovese L. An overview of the beneficial effects of hydrolysed collagen as a nutraceutical on skin properties: scientific background and clinical studies. The Open Nutraceuticals Journal 8; 2015. p. 29-42.
[2] Boelsma E, Vijver LPLV, Goldbohm RA, Klöpping-Ketelaars IAA, Hendriks HFJ, Roza L. Human skin condition and its associations with nutrient concentrations in serum and diet. Am J Clin Nutr 77; 2003. p. 348–55.
[3] Liu D, Nikoo M, Boran G, Zhou P, Regenstein JM. Collagen and Gelatin. Annu. Rev. Food Sci. Technol. 6; 2015. p. 527–57.
[4] Choi SY, Ko EJ, Lee YH, Kim BG, Shin HJ, Seo DB, Lee SJ, Kim BJ, Kim MN. Effects of collagen tripeptide supplement on skin properties: A prospective, randomized, controlled study. Journal of Cosmetic and Laser Therapy 16:3; 2014. p. 132-7.
[5] Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis. Skin Pharmacol Physiol 27; 2014. p. 113–119.
[6] Matsuda N, Koyama Y, Hosaka Y, Ueda H, Watanabe T, Araya T, Irie S. Takehana K.Effects of the ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in the Dermis. Journal Nutr Vitaminol 15; 2006. p. 52- 211.

Bones and Joints

Keeping your joints and bones healthy is essential for a better quality of life. Factors such as age, or repetitive stress of the joints are among the most damaging factors of bone and joint health. Intake of collagen peptides has been associated with beneficial health effects of bones, joints and ligaments of the body [2].

Collagen has an important structural function in the bones and cartilage within our body. Several scientific studies have demonstrated the benefits of ingestion of collagen peptides for our health:

Scientific research supports that the use of collagen peptides helps maintain healthier joints [1]

Among its potential benefits, it also emphasizes the strengthening of bone metabolism [3].

It may also contribute to reducing discomfort and improving joint mobility [4].

Positive effects were observed in a study to reduce degenerative problems by stimulating the anabolic process of cartilaginous tissues [5].

Pain symptoms that associated with physical exercise, are reduced [6].

[1] Bello AE, Oesser S. Collagen Hydrolysate for the treatment of osteoarthritis and other joint disorders. Current Medical Research an Opinion 22; 2006. p. 2221-32.[1] Bello AE, Oesser S. Collagen Hydrolysate for the treatment of osteoarthritis and other joint disorders. Current Medical Research an Opinion 22; 2006. p. 2221-32.[2] Kim HK, Kim MG, Leem KH. Osteogenic Activity of Collagen Peptide via ERK/MAPK Pathway Mediated Boosting of Collagen Synthesis and Its Therapeutic Efficacy in Osteoporotic Bone by Back-Scattered Electron Imaging and Microarchitecture Analysis. Molecules, 18; 2013. p. 15474-89.[3] Guillerminet F, Beaupied H, Fabien-Soulé V, Tomé D, Benhamou CL, Roux C, Blais A. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: An in vitro and in vivo study. Elsevier, Bone 46; 2010. p. 827–34. [4] Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN, Maestanza-Peralta MA, Vallejo-Flores CA, Vargas-López SV et al. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. International Journal of food sciences and nutrition, 60 (S2); 2009. p. 99-113.[5] Schunk M, Schulze CH, Oesser S. Collagen hydrolysate supplementation stimulates proteoglycan metabolism and gene expression of articular chondrocytes. International Cartilage Repair Society Poster 189; 2007.[6] Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza  F, Millard  RL, Deitch JR, Sherbondy PS, Albert A. 24 week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion 24; 2008. p. 1485–96.

Nutrition and weight maintenance

Intake of adequate levels of protein is essential in keeping the body lean and providing adequate amounts of amino acids to our body [1].
Studies have shown that collagen peptides have been strong allies for reducing appetite, helping patients suffering from obesity to adopt a more effective and healthy diet [2].
Collagen peptides have also been shown to be a great supplement option for older people, maintaining lean mass and providing better quality of life [1].

[1] Hays NP, Kim H, Wells AM, Kajkenova O, Evans WJ. Effects of Whey and Fortified Collagen Hydrolysate Protein Supplements on Nitrogen balance and Body Composition in Older Women. J Am Diet Assoc. 109; 2009. p. 1082-7.
[2] Rubio IGS, Castro G, Zanini AC, Medeiros-Neto G. Oral ingestion of a hydrolyzed gelatin meal in subjects with normal weight and in obese patients: Postprandial effect on circulating gut peptides, glucose and insulin. 13; 2008. p. 48-53.